Lactobacillus rhamnosus B16 regulates lipid metabolism homeostasis by producing acetic acid
HI-L. rB16 alleviates HFD-induced hyperlipidemia in mice by reducing cholesterol through acetate-mediated LXRα signaling, demonstrating its therapeutic potential as a probiotic for lipid metabolism disorders.
Authors
- Shiyi Wen (ORCID: https://orcid.org/0009-0007-9825-6432)
- Yanfang Liang (ORCID: https://orcid.org/0009-0006-6521-452X)
- Jincheng Zeng (ORCID: https://orcid.org/0000-0001-6196-3917)
- Haibo Yu (ORCID: https://orcid.org/0000-0002-1744-990X)
- Xingxing Chai (ORCID: https://orcid.org/0000-0002-5894-8860)
- Bihua Lin
- Zhengping Che (ORCID: https://orcid.org/0000-0001-6818-1125)
- Shaobing Zhang (ORCID: https://orcid.org/0000-0001-7532-6994)
- Juan Huang (ORCID: https://orcid.org/0000-0003-3072-4352)
- Ziyu Ye (ORCID: https://orcid.org/0000-0003-2659-5818)
Institutions
- Chongqing University (CN)
- Guangdong Medical College (CN)
- Key Laboratory of Guangdong Province (CN)
- Dongguan People’s Hospital (CN)
- Tang Hospital (CN)
- Guhua Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1186/s12967-025-07228-1
- Citations
- 5
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 6.77