Nicotinamide riboside attenuates radiation-induced intestinal injury by suppressing gasdermin E-mediated pyroptosis in intestinal epithelial cells
Our study demonstrated that NR mitigates IR by inhibiting GSDME-mediated pyroptosis and restoring IECs homeostasis. These findings suggest that NR could serve as a promising therapeutic strategy for IR following radiotherapy.
Authors
- Binhai Shen
- Weiguang Qiao (ORCID: https://orcid.org/0000-0001-8423-0724)
- Qian Zhou (ORCID: https://orcid.org/0000-0002-8433-2875)
- Fachao Zhi (ORCID: https://orcid.org/0000-0001-8674-4737)
- Yuyi Yang
- Xinlong Lin
- Gao Tan (ORCID: https://orcid.org/0000-0002-6959-2249)
- Wendi Zhang (ORCID: https://orcid.org/0000-0002-6127-1408)
- Xinmei Zhao (ORCID: https://orcid.org/0000-0003-3940-788X)
- Yangyang Liu (ORCID: https://orcid.org/0000-0003-2851-660X)
- Hongbin Liu (ORCID: https://orcid.org/0000-0002-5840-2374)
- Xiaoyang Li (ORCID: https://orcid.org/0000-0002-4046-2934)
- Weifeng Huang (ORCID: https://orcid.org/0000-0001-8546-1591)
- Yin Zhang (ORCID: https://orcid.org/0000-0002-0025-0873)
- Yinmu Li
Institutions
- Nanfang Hospital (CN)
- Southern Medical University Shenzhen Hospital (CN)
- Kai Biotech (South Korea) (KR)
- Southern Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1186/s12967-025-07012-1
- Primary Topic
- Effects of Radiation Exposure
- Type
- article
- Field-Weighted Citation Impact
- 0.00