Targeted Tissue Perfusion Versus Macrocirculatory-Guided Standard Care in Patients With Septic Shock: A Randomized Clinical Trial—The TARTARE-2S Trial
In ICU patients with septic shock and lactate greater than 3 mmol/L, targeting tissue perfusion and allowing lower than recommended MAP did not increase the number of days alive with normal lactate and without vasopressor/inotropic drugs at 30 days. No additional safety concerns with the TTP strategy were detected compared with SC.
Authors
- Johanna Hästbacka (ORCID: https://orcid.org/0000-0002-3613-7231)
- Ville Pettilä
- Anders Perner (ORCID: https://orcid.org/0000-0002-4668-0123)
- Paul Lombardo (ORCID: https://orcid.org/0000-0003-2519-3358)
- Tuomas A. Selander (ORCID: https://orcid.org/0000-0002-0070-8565)
- Tobias M. Merz (ORCID: https://orcid.org/0000-0002-3149-5873)
- Erika Wilkman (ORCID: https://orcid.org/0000-0003-4250-7523)
- Matthias Läng (ORCID: https://orcid.org/0000-0001-7962-143X)
- Stephan M. Jakob (ORCID: https://orcid.org/0000-0002-2195-0473)
- Jukka Takala
- Carmen Andrea Pfortmüller
Institutions
- University of Bern (CH)
- University of Copenhagen (DK)
- University of Helsinki (FI)
- Helsinki University Hospital (FI)
- University Hospital of Bern (CH)
- Auckland City Hospital (NZ)
- Copenhagen University Hospital (DK)
- Rigshospitalet (DK)
- Azienda Ospedaliera Citta' della Salute e della Scienza di Torino (IT)
- Kuopio University Hospital (FI)
- Tampere University Hospital (FI)
- Tampere University (FI)
Publication Details
- Journal
- Critical Care Medicine
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1097/ccm.0000000000006899
- Citations
- 2
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.71