Multiparametric MRI assessment of acute neuroinflammation in a murine model of peripheral LPS stimulation
The present findings highlight the potential of non-contrast-enhanced MRI to assess acute neuroinflammation-related changes in several mouse brain areas upon peripheral LPS stimulation. The assessment of multiple parameters provided sufficient sensitivity to detect pharmacological modulation of the neuroinflammatory response elicited by the endotoxin.
Authors
- Nicolau Beckmann (ORCID: https://orcid.org/0000-0001-7636-9240)
- Anna Neuhaus
- Stefan Zurbruegg
- F. Gasparini (ORCID: https://orcid.org/0000-0002-1315-563X)
- Derya R. Shimshek (ORCID: https://orcid.org/0000-0001-8602-7850)
- Anna Schubart (ORCID: https://orcid.org/0000-0003-4253-0600)
Institutions
- Novartis (Switzerland) (CH)
Publication Details
- Journal
- BMC Medical Imaging
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1186/s12880-025-01962-0
- Primary Topic
- Long-Term Effects of COVID-19
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Novartis Pharma