Effectiveness of Nirsevimab in Preventing Respiratory Syncytial Virus-related Burden: A Test-negative Case-control Study in Infants With Bronchiolitis in Lombardy Region, Italy
The effectiveness of nirsevimab in preventing the burden of respiratory syncytial virus (RSV)-bronchiolitis was evaluated with a test-negative case-control study in 208 infants presenting to Emergency Department. The effectiveness was 82% against RSV infection, 78% against RSV-related hospitalization, and 84% against intensive care admission. These real-world data support its inclusion in Italian immunization programs.
Authors
- Laura Folgori (ORCID: https://orcid.org/0000-0002-0680-0450)
- Giovanni Chiaffoni
- Lucia Barcellini (ORCID: https://orcid.org/0000-0003-2049-3968)
- Valentina Fabiano (ORCID: https://orcid.org/0000-0001-6449-1724)
- Anna Banfi
- Eleonora Fusco (ORCID: https://orcid.org/0000-0002-9629-2372)
- Federica Forlanini (ORCID: https://orcid.org/0000-0001-7812-6322)
- Martina Loiodice (ORCID: https://orcid.org/0009-0002-7025-3348)
- Sara L’assainato
- Francesca Izzo (ORCID: https://orcid.org/0000-0003-2924-6904)
- Gianvincenzo Zuccotti (ORCID: https://orcid.org/0000-0002-2795-9874)
- Valentina De Giorgis (ORCID: https://orcid.org/0000-0002-5828-7070)
- Cecilia Porro
- Alice Romero
Institutions
- University of Milan (IT)
- Ospedale dei Bambini Vittore Buzzi (IT)
Publication Details
- Journal
- The Pediatric Infectious Disease Journal
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1097/inf.0000000000004968
- Citations
- 1
- Primary Topic
- Respiratory viral infections research
- Type
- article
- Field-Weighted Citation Impact
- 1.35