Cardiomyocyte‐Specific Deletion of Sirtuin 5 Accelerates the Development of Heart Failure Upon Dysregulating Purine Metabolism
Loss of SIRT5 in cardiomyocytes aggravates cardiac remodeling and dysfunction in response to chronic pressure overload, involving ATP precursor depletion due to transcriptional dysregulation of cardiac purine metabolism.
Authors
- Sibai Tang
- Dirk von Lewinski (ORCID: https://orcid.org/0000-0001-9996-6128)
- Aleksandre Tarkhnishvili (ORCID: https://orcid.org/0000-0002-8333-8300)
- Andreas Zirlik (ORCID: https://orcid.org/0000-0001-6290-3297)
- Senka Ljubojević-Holzer (ORCID: https://orcid.org/0000-0001-6994-9976)
- Katharina Pfeil
- Peter P. Rainer (ORCID: https://orcid.org/0000-0002-2840-6454)
- Ivan Vosko (ORCID: https://orcid.org/0000-0002-6198-888X)
- Michael M. Hoffmann (ORCID: https://orcid.org/0000-0001-8459-6080)
- Johannes Gollmer (ORCID: https://orcid.org/0000-0002-8734-6359)
- Christoph Koentges (ORCID: https://orcid.org/0000-0002-2074-7182)
- Julia Lueg (ORCID: https://orcid.org/0000-0001-7905-704X)
- Harald Sourij (ORCID: https://orcid.org/0000-0003-3510-9594)
- Sayan Bakshi (ORCID: https://orcid.org/0000-0002-6717-6049)
- Markus Wallner (ORCID: https://orcid.org/0000-0001-7692-892X)
- Landon Wilson (ORCID: https://orcid.org/0000-0002-0246-6491)
- Katja E. Odening (ORCID: https://orcid.org/0000-0001-6999-841X)
- Simon Sedej (ORCID: https://orcid.org/0000-0002-4419-6821)
- Adam R. Wende (ORCID: https://orcid.org/0000-0002-5536-4675)
- Clara Rau
- Nikole J. Byrne (ORCID: https://orcid.org/0000-0002-0006-7147)
- Stephen Barnes (ORCID: https://orcid.org/0000-0001-7961-0837)
- Heiko Bugger (ORCID: https://orcid.org/0000-0002-3524-0405)
- Thomas Rathner
- Christoph Bode
- Stephan Birkle
- Laura C. Birkle
Institutions
- University of Freiburg (DE)
- Medical University of Graz (AT)
- University Hospital of Bern (CH)
- University Medical Center Freiburg (DE)
- University of Alabama at Birmingham (US)
- University of Maribor (SI)
- BioTechMed-Graz (AT)
Publication Details
- Journal
- Acta Physiologica
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1111/apha.70120
- Citations
- 1
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 1.22
Funders
- American Heart Association
- Deutsche Forschungsgemeinschaft
- Austrian Science Fund
- Peter und Traudl Engelhorn Stiftung
- European Research Area Network on Cardiovascular Diseases
- National Institutes of Health