Synthesis of α-Amino Acids by ConPET-Mediated CO <sub>2</sub> Fixation into Amides
Herein, we report a photocatalytic method for the selective functionalization of α-C(sp3)-H bonds adjacent to the nitrogen atom in amides. By harnessing a synergistic combination of hydrogen atom transfer (HAT), consecutive photoinduced electron transfer (ConPET), and reductive radical-polar crossover, we efficiently incorporated high-value electrophiles, including CO2, 13CO2, and deuterium, at the α-N position. The transformation proceeds in moderate to high yields across a diverse range of amides, representing a significant advancement in both isotopically labeled α-amino acid synthesis and amide deuteration.
Authors
- Marco A. B. Ferreira (ORCID: https://orcid.org/0000-0002-4954-6691)
- Márcio W. Paixão (ORCID: https://orcid.org/0000-0002-0421-2831)
- Kimberly Benedetti Vega (ORCID: https://orcid.org/0000-0002-4440-132X)
- Tanumoy Mandal
- Attilio C. Neto (ORCID: https://orcid.org/0000-0002-4266-4409)
- Ruth M. Gschwind (ORCID: https://orcid.org/0000-0003-3052-0077)
- Burkhard Koenig (ORCID: https://orcid.org/0000-0002-6131-4850)
- Wagner Silva (ORCID: https://orcid.org/0000-0001-8200-7748)
- Alejandro Heredero Sánchez
Institutions
- Universidade Federal de São Carlos (BR)
- University of Regensburg (DE)
Publication Details
- Journal
- ACS Catalysis
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1021/acscatal.5c04666
- Citations
- 3
- Primary Topic
- Advanced Synthetic Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 2.81