The effects of genetically determined plasma methyltransferases on digestive system cancers: a comprehensive bidirectional two-sample Mendelian randomization analysis
This study reveals that certain methyltransferases are associated with an increased risk of some digestive system cancers. HEMK2 and NTMT1 emerged as candidate genetically predicted biomarkers, meriting further research to elucidate their mechanistic functions and potential clinical applicability. Furthermore, as all genetic information in this study originates from European cohorts, the conclusions are primarily relevant to this population and necessitate validation in diverse ethnic groups.
Authors
- Zhebin Dong
- Yihui Weng (ORCID: https://orcid.org/0000-0003-0042-3188)
- Weiming Yu (ORCID: https://orcid.org/0000-0002-3024-2938)
- Xianlei Cai (ORCID: https://orcid.org/0000-0001-9242-0982)
- Xueying Li (ORCID: https://orcid.org/0000-0002-1100-4694)
Institutions
- Ningbo University (CN)
- Ningbo Medical Center Lihuili Hospital (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1007/s12672-025-03758-8
- Primary Topic
- Cancer-related gene regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Ningbo
- Medical Science and Technology Project of Zhejiang Province
- Natural Science Foundation of Zhejiang Province
- Science and Technology Program of Zhejiang Province