Runx2 downregulates Lpl expression through super-silencer formation to alter lipid metabolism in Zhu Schwann cells after nerve injury
Runx2 can modulate the biological behavior of SCs by forming super-silencers that interfere with the expression of lipid metabolism genes, such as Lpl, thereby altering the metabolic capacity of SCs.
Authors
- Yangbin Xu (ORCID: https://orcid.org/0000-0002-2587-9619)
- Bo He (ORCID: https://orcid.org/0000-0002-9690-4527)
- Guanggeng Wu (ORCID: https://orcid.org/0009-0009-0778-7882)
- Vincent Pang (ORCID: https://orcid.org/0000-0002-9403-5604)
- Zhaowei Zhu (ORCID: https://orcid.org/0000-0003-2890-0169)
- Yujing Zhang (ORCID: https://orcid.org/0000-0003-1180-0444)
- Ge Li (ORCID: https://orcid.org/0000-0001-9030-884X)
- Yan Yang (ORCID: https://orcid.org/0009-0008-0237-9188)
- Xiang Zhou (ORCID: https://orcid.org/0000-0002-4904-4245)
- Rui Kuang
- Shouwen Su
- Yu Zhang (ORCID: https://orcid.org/0009-0005-6052-7087)
Institutions
- Sun Yat-sen University (CN)
- Guangzhou Institute of Dermatology (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- First Hospital of China Medical University (CN)
- Guangdong Academy of Medical Sciences (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
- China Medical University (CN)
Publication Details
- Journal
- Cellular & Molecular Biology Letters
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1186/s11658-025-00796-6
- Primary Topic
- Nerve injury and regeneration
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province
- Guangdong Provincial People's Hospital
- Guangzhou Municipal Science and Technology Project
- Basic and Applied Basic Research Foundation of Guangdong Province