Utilizing resting motor threshold to predict cognitive function in drug-naive patients with major depressive disorder
This exploratory study is the first to demonstrate that RMT can predict verbal learning ability, attention, and vigilance in male patients with MDD, whereas no significant correlation was observed in female patients. This finding reveals RMT's potential significance and highlights that sex differences necessitate consideration when developing rTMS-based treatment regimens targeting both antidepressant and cognitive outcomes. Further longitudinal studies with larger sample sizes are needed to validate its clinical relevance.
Authors
- Jing He (ORCID: https://orcid.org/0000-0002-1954-2892)
- Ya Jin (ORCID: https://orcid.org/0000-0001-6095-0882)
- Fan Yang (ORCID: https://orcid.org/0000-0001-6133-0706)
- Chao Li (ORCID: https://orcid.org/0009-0004-1777-5432)
- Limin Feng (ORCID: https://orcid.org/0000-0002-2249-3817)
- Jianzhong Yang (ORCID: https://orcid.org/0000-0002-7308-0123)
- Lei Yang (ORCID: https://orcid.org/0000-0002-0418-6987)
- Li Xu
- Decai Du (ORCID: https://orcid.org/0000-0002-6758-0113)
Institutions
- Kunming Medical University (CN)
- First Affiliated Hospital Zhejiang University (CN)
Publication Details
- Journal
- BMC Psychiatry
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1186/s12888-025-07393-z
- Primary Topic
- Transcranial Magnetic Stimulation Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00