Investigation into the molecular mechanism of obesity: an integrated approach of multi-omics analysis, machine learning and experimental validation
This study identified TREM2 as a key effector in the regulation of obesity-related pathophysiological processes, with specific expression in macrophages. These findings collectively position TREM2 as a potential diagnostic biomarker for obesity.
Authors
- Congai Chen
- Jingwei Mao (ORCID: https://orcid.org/0000-0003-1896-1988)
- Yiwen Deng (ORCID: https://orcid.org/0000-0002-6074-5704)
- Jun Zhou (ORCID: https://orcid.org/0009-0008-7533-8926)
- Limin Nie (ORCID: https://orcid.org/0000-0001-7647-9255)
- Fan Yang (ORCID: https://orcid.org/0000-0002-3000-2336)
- Tangfeng Lv (ORCID: https://orcid.org/0000-0001-7224-8468)
- Luopeng Zhao (ORCID: https://orcid.org/0000-0002-9694-8669)
- Bin Li (ORCID: https://orcid.org/0000-0002-5717-1551)
- Yuanyuan Li (ORCID: https://orcid.org/0000-0002-7263-936X)
- Lu Liu (ORCID: https://orcid.org/0000-0001-8023-7187)
- Ruiqing Wang (ORCID: https://orcid.org/0000-0003-3477-4314)
- Xiaobo Ge (ORCID: https://orcid.org/0000-0002-7802-0437)
Institutions
- Beijing University of Chinese Medicine (CN)
- Capital Medical University (CN)
- Beijing Hospital of Traditional Chinese Medicine (CN)
- First Affiliated Hospital of Henan University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1186/s12967-025-07096-9
- Citations
- 2
- Primary Topic
- Bioinformatics and Genomic Networks
- Type
- article
- Field-Weighted Citation Impact
- 1.61