Lactate dehydrogenase a is a crucial biomarker that affects the prognosis, chemotherapy effect, and immune infiltration of breast cancer
Our findings suggest that LDHA expression and serum LDH levels are promising prognostic biomarkers for survival and may predict chemotherapy response in BC patients. These results highlight the clinical relevance of LDHA-mediated metabolic pathways. However, as a correlational study, our findings warrant further validation through functional experiments to confirm LDHA's role as a potential therapeutic target.
Authors
- Dan Luo (ORCID: https://orcid.org/0000-0001-9621-7252)
- Min Xiao (ORCID: https://orcid.org/0000-0001-8077-453X)
- He Dou (ORCID: https://orcid.org/0000-0002-5317-8289)
- Jia Nan Wang
- S. Jia
- Jiliang Xia (ORCID: https://orcid.org/0000-0003-1749-7810)
- Fuze Li
- Xue Lian Li
- Z Li
- Tian Gao (ORCID: https://orcid.org/0000-0002-8561-4540)
- Yi Lin Wang
- Y. Ba
Institutions
- Harbin Medical University (CN)
- Third Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- BMC Women s Health
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1186/s12905-025-04039-w
- Citations
- 1
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Harbin Medical University
- National Natural Science Foundation of China