Drug survival of systemic treatments for severe paediatric psoriasis: An international retrospective study
This cohort study showed that acitretin and methotrexate had comparable 2-year drug survival rates, which were superior to cyclosporine. We did not find any predictive factors for increased treatment maintenance except for first-line use of acitretin. AEs were a frequent reason for discontinuing treatments. These results may help develop treatment algorithms for systemic therapy in paediatric psoriasis.
Authors
- Sophie Leducq (ORCID: https://orcid.org/0000-0002-4860-6365)
- S. Mallet (ORCID: https://orcid.org/0000-0003-2884-0645)
- Tess McPherson (ORCID: https://orcid.org/0000-0001-9215-0302)
- E. Mahé (ORCID: https://orcid.org/0000-0001-5780-1827)
- C. Chiavérini (ORCID: https://orcid.org/0000-0002-6063-5409)
- A.‐C. Bursztejn (ORCID: https://orcid.org/0000-0002-3281-7299)
- Thomas Hubiche (ORCID: https://orcid.org/0000-0002-3247-7386)
- M. Tardieu (ORCID: https://orcid.org/0000-0002-4996-3567)
- N. Sigg
- Kamal Patel (ORCID: https://orcid.org/0000-0003-2611-4260)
- Cristina Bertoli
- Carsten Flohr (ORCID: https://orcid.org/0000-0003-4884-6286)
- S. Barbarot (ORCID: https://orcid.org/0000-0002-6629-9100)
- B. Bonniaud
- Iria Neri (ORCID: https://orcid.org/0000-0002-8552-0771)
- M. Sergeant
- Maryam Piram (ORCID: https://orcid.org/0000-0002-8634-5530)
- Esther Burden‐Teh (ORCID: https://orcid.org/0000-0002-0033-2836)
- Vito Giuseppe Di Lernia (ORCID: https://orcid.org/0000-0002-8961-7108)
- Christine Bodemer (ORCID: https://orcid.org/0000-0001-8772-0905)
- A. Lasek (ORCID: https://orcid.org/0000-0002-4105-4027)
- E. Puzenat
- H. Aubert (ORCID: https://orcid.org/0000-0003-1688-9900)
- Tiago Torres (ORCID: https://orcid.org/0000-0003-0404-0870)
- Alain Beauchet (ORCID: https://orcid.org/0000-0001-6339-982X)
- Francesca Prignano (ORCID: https://orcid.org/0000-0002-5997-2045)
- Marco Adriano Chessa (ORCID: https://orcid.org/0000-0002-0149-8870)
- D. Pourchot
- J. Miquel (ORCID: https://orcid.org/0000-0002-7198-8322)
- Yu Miao
- Yasmine Yesli
Institutions
- Université de Tours (FR)
- Hôpital Necker-Enfants Malades (FR)
- University of Nottingham (GB)
- Inserm (FR)
- Université Catholique de Lille (FR)
- Guy's and St Thomas' NHS Foundation Trust (GB)
- Centre Hospitalier Universitaire de Grenoble (FR)
- Centre Hospitalier Universitaire Sainte-Justine (CA)
- Centre Hospitalier Universitaire de Nantes (FR)
- Assistance Publique Hôpitaux de Marseille (FR)
- Centre Hospitalier Universitaire de La Réunion (RE)
- Centre Hospitalier Universitaire de Besançon (FR)
- Centre Hospitalier Universitaire de Tours (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Centre Hospitalier Régional et Universitaire de Nancy (FR)
- Centre Hospitalier Intercommunal de Poissy (FR)
- Centre Hospitalier Universitaire d'Angers (FR)
- Ospedale Santa Maria (IT)
- CHU Dijon Bourgogne (FR)
- Hôpital l'Archet (FR)
- Azienda USL di Bologna (IT)
- Hospital de Santo António (PT)
- Hôpital Raymond-Poincaré (FR)
- Centre Hospitalier Victor Dupouy (FR)
- Oxford University Hospitals NHS Trust (GB)
- Centre Hospitalier Universitaire de Saint-Pierre (BE)
- Hôpital Saint-Vincent-de-Paul (FR)
- University of Florence (IT)
Publication Details
- Journal
- Journal of the European Academy of Dermatology and Venereology
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1111/jdv.70108
- Citations
- 3
- Primary Topic
- Psoriasis: Treatment and Pathogenesis
- Type
- article
- Field-Weighted Citation Impact
- 2.39