Microbiota-gut-brain axis dysregulation in Alzheimer’s disease and its modulation through probiotic supplementation
These findings confirmed the presence of MGBA alterations in AD and suggested a potential beneficial effect of probiotic supplementation through modulation of GM functionality rather than composition. Further research is required to confirm these results and their clinical relevance.
Authors
- Veronica Begni (ORCID: https://orcid.org/0000-0003-2244-1782)
- Peppino Mirabelli (ORCID: https://orcid.org/0000-0002-2183-7577)
- Davide Vito Moretti (ORCID: https://orcid.org/0000-0003-0611-1169)
- Dominic Salamone (ORCID: https://orcid.org/0000-0002-5655-9036)
- Fabrizio Piazza (ORCID: https://orcid.org/0000-0002-3385-3224)
- Melissa Rosa (ORCID: https://orcid.org/0000-0001-8463-9968)
- Silvia Alboni
- Elisa Mombelli (ORCID: https://orcid.org/0000-0002-7625-3245)
- Luigi Coppola (ORCID: https://orcid.org/0000-0002-3222-3730)
- Annamaria Cattaneo (ORCID: https://orcid.org/0000-0002-9963-848X)
- Marco Salvatore (ORCID: https://orcid.org/0000-0001-9734-7702)
- Moira Marizzoni (ORCID: https://orcid.org/0000-0003-3749-2988)
- Samantha Saleri
- Giovanni B. Frisoni (ORCID: https://orcid.org/0000-0001-7075-7082)
- Delia Luongo
Institutions
- University of Geneva (CH)
- University of Modena and Reggio Emilia (IT)
- Centro San Giovanni di Dio Fatebenefratelli (IT)
- Federico II University Hospital (IT)
- Santobono Children's Hospital (IT)
- Institute of Biostructure and Bioimaging (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- University of Milano-Bicocca (IT)
- University of Naples Federico II (IT)
Publication Details
- Journal
- Brain Behavior and Immunity
- Published
- 2025-10-13
- DOI
- https://doi.org/10.1016/j.bbi.2025.106138
- Citations
- 1
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Alzheimer's Association
- Biogen
- Ministero della Salute
- Eisai
- Hôpitaux Universitaires de Genève
- Fondation Segré