Integrated single-cell and Mendelian randomization analyses: dissecting underlying causes of varied efficacy in immune neoadjuvant therapy for esophageal carcinoma
The study highlights CD4⁺T cells' predictive role in therapy efficacy via scRNA-seq and MR. PLTP emerges as a key gene, offering new precision medicine strategies for esophageal cancer.
Authors
- Sibo Meng
- Ying Zhou (ORCID: https://orcid.org/0000-0001-8992-7897)
- Jiaxin Li (ORCID: https://orcid.org/0000-0002-1681-3271)
- Yufeng Cheng
Institutions
- Qingdao University (CN)
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-10-16
- DOI
- https://doi.org/10.1007/s12672-025-03751-1
- Primary Topic
- Esophageal Cancer Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- BeiGene
- National Natural Science Foundation of China
- Universidade de Macau
- Natural Science Foundation of Shandong Province
- Fundamental Research Funds for the Central Universities