Aging Accelerates Degradation of Human Neuromuscular Junction Following Peripheral Nerve Injury
Our study shows that age does affect the MEP response to injury. This effect is most significant in MEP innervation, with rapid loss of visible innervated terminals in the older group. Surprisingly, there was no significant difference in MEP morphology in the older patients, suggesting that early surgical intervention may still offer significant recovery potential.
Authors
- Oswald Steward (ORCID: https://orcid.org/0000-0001-7069-8756)
- Vivian Y. Chen (ORCID: https://orcid.org/0000-0002-8038-9719)
- Luigi P. Gonzales (ORCID: https://orcid.org/0000-0003-3509-1718)
- David J. Wright (ORCID: https://orcid.org/0000-0001-5952-2602)
- Tyler Robert Johnston (ORCID: https://orcid.org/0000-0002-9262-0527)
- Ranjan Gupta (ORCID: https://orcid.org/0000-0003-3965-5410)
- Saman Andalib (ORCID: https://orcid.org/0009-0002-3281-8256)
- Amanda Tedesco (ORCID: https://orcid.org/0009-0009-2227-8840)
- Tahseen Mozaffar (ORCID: https://orcid.org/0000-0002-1230-0188)
- Christopher Lee (ORCID: https://orcid.org/0000-0002-4589-4023)
Institutions
- University of California, Irvine (US)
- Irvine University (US)
Publication Details
- Journal
- Muscle & Nerve
- Published
- 2025-08-14
- DOI
- https://doi.org/10.1002/mus.70003
- Citations
- 1
- Primary Topic
- Muscle activation and electromyography studies
- Type
- article
- Field-Weighted Citation Impact
- 0.67