Soluble BDCA-2 as a potential biomarker for rheumatoid arthritis and its role in enhancing IFN-α production through nucleic acid binding
These findings show that solBDCA-2 enhances type I interferon production by forming immunostimulatory complexes with DNA and RNA. Dysregulated solBDCA-2 expression might contribute to RA pathogenesis.
Authors
- Francisco Venegas Solis (ORCID: https://orcid.org/0000-0001-5799-8711)
- Ricardo Grieshaber‐Bouyer (ORCID: https://orcid.org/0000-0002-2873-5135)
- Stefan Bauer (ORCID: https://orcid.org/0000-0002-8462-1845)
- Andreas Kaufmann (ORCID: https://orcid.org/0000-0002-3936-5379)
- Laura Bucci (ORCID: https://orcid.org/0000-0003-0449-6392)
- Lisa Mainieri
Institutions
- Philipps University of Marburg (DE)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Universitätsklinikum Erlangen (DE)
- Institute of Medical Microbiology and Hygiene (DE)
Publication Details
- Journal
- Lara D. Veeken
- Published
- 2025-10-16
- DOI
- https://doi.org/10.1093/rheumatology/keaf537
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00