Prospective multicentre single-arm study of an interatrial shunt in heart failure with reduced ejection fraction (SUSTAIN-HF): 1-year clinical and haemodynamic outcomes
In this prospective cohort study of symptomatic HFrEF patients, treatment with the D-Shant atrial shunt device was associated with significant improvements in functional capacity, quality of life and rates of heart failure hospitalisation at 1 year. The single-arm design precludes definitive conclusions on treatment efficacy, underscoring the need for randomised, sham-controlled trials.
Authors
- Nianguo Dong (ORCID: https://orcid.org/0000-0001-5080-4523)
- Jian Yang (ORCID: https://orcid.org/0000-0003-4250-1391)
- Mei Liu (ORCID: https://orcid.org/0000-0002-7073-6174)
- Qingwei Ji (ORCID: https://orcid.org/0000-0002-6846-5619)
- Changyu Qin
- Xiaoke Shang (ORCID: https://orcid.org/0000-0002-3263-5428)
- Qiaozhen Li
- Yan Li (ORCID: https://orcid.org/0000-0003-3901-0727)
- Song Chen (ORCID: https://orcid.org/0000-0001-6412-5740)
- Qing Kenneth Wang (ORCID: https://orcid.org/0000-0002-2235-6572)
- Ming Sun (ORCID: https://orcid.org/0009-0002-5450-7512)
- Xueli Wang (ORCID: https://orcid.org/0000-0002-8382-9425)
- Geng Li (ORCID: https://orcid.org/0000-0001-6478-2732)
- Yucheng Zhong (ORCID: https://orcid.org/0000-0002-0341-655X)
- Xiaoping Peng (ORCID: https://orcid.org/0000-0001-9401-2106)
- Changdong Zhang (ORCID: https://orcid.org/0009-0007-5417-8305)
- Guangyuan Song (ORCID: https://orcid.org/0000-0002-7868-6132)
- Jun Tian (ORCID: https://orcid.org/0000-0002-5949-3685)
Institutions
- Nanchang University (CN)
- Shanxi Medical University (CN)
- Huazhong Agricultural University (CN)
- Xi'an Medical University (CN)
- The People's Hospital of Guangxi Zhuang Autonomous Region (CN)
- Beijing Anzhen Hospital (CN)
- First Hospital of Shanxi Medical University (CN)
- Wuhan Union Hospital (CN)
- Second Hospital of Shanxi Medical University (CN)
- Wuhan Children's Hospital (CN)
- Huazhong University of Science and Technology Hospital (CN)
- First Affiliated Hospital of Nanchang University (CN)
- Huazhong University of Science and Technology (CN)
- Hubei University of Technology (CN)
Publication Details
- Journal
- Heart
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1136/heartjnl-2025-326319
- Primary Topic
- Cardiac Arrhythmias and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00