SMYD2-mediated methylation of STAT1 protects against hepatic ischaemia/reperfusion injury by blocking JAK-STAT1 signalling pathways
This study establishes SMYD2 as a novel negative regulator of STAT1 activity through K175 methylation, providing new insights into the epigenetic control of STAT1 during hepatic I/R injury. Our findings reveal a previously unrecognised mechanism for fine-tuning STAT1 signalling in hepatic I/R injury, and targeting the SMYD2-STAT1 axis may present a promising therapeutic strategy for mitigating I/R-associated liver damage.
Authors
- Yuanbao Chen (ORCID: https://orcid.org/0009-0000-5849-091X)
- Shanyu Gan
- Chunyong Yang (ORCID: https://orcid.org/0000-0002-6848-5919)
- Yufeng Hu (ORCID: https://orcid.org/0000-0002-9416-262X)
- Bin Yi (ORCID: https://orcid.org/0000-0001-5840-2086)
- Zhongxue Wu (ORCID: https://orcid.org/0009-0006-4463-6395)
- Yujie Li (ORCID: https://orcid.org/0000-0003-3527-5859)
- Xiao‐Jing Zhang (ORCID: https://orcid.org/0000-0002-8271-7405)
- Hongliang Li (ORCID: https://orcid.org/0000-0002-9821-0297)
- Lin Chen (ORCID: https://orcid.org/0000-0003-0997-1869)
- Junjie Zhou (ORCID: https://orcid.org/0000-0002-9588-9839)
- X Zhong
- Guisheng Qi
- Ying Zuo
- Ziyang Zeng (ORCID: https://orcid.org/0009-0003-7807-6152)
- Zhiyong Yang (ORCID: https://orcid.org/0000-0003-1311-4931)
Institutions
- Army Medical University (CN)
- Gannan Medical University (CN)
- Southwest Hospital (CN)
- First People's Hospital of Chongqing (CN)
Publication Details
- Journal
- Gut
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1136/gutjnl-2025-336400
- Primary Topic
- Cytokine Signaling Pathways and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00