Proteomic profiling of bone tissue reveals distinct pathways in men and women with osteoporosis
This study identified sex-specific proteomic profiles and molecular pathways associated with osteoporosis, with ageing emerging as a central upstream driver of these differences. These findings may help elucidate the sex differences in the pathogenesis of osteoporosis and provides a foundation for the discovery of new therapeutic targets and the development of personalised precision treatment strategies.
Authors
- Weibo Xia (ORCID: https://orcid.org/0000-0001-7768-5536)
- Hengyan Zhang (ORCID: https://orcid.org/0000-0001-6549-0002)
- Yan Jiang (ORCID: https://orcid.org/0000-0003-4434-3462)
- Lei Sun (ORCID: https://orcid.org/0000-0002-7864-0337)
- Mei Li (ORCID: https://orcid.org/0000-0001-8634-2252)
- Xiaoyun Lin
- Jia Zhang (ORCID: https://orcid.org/0000-0002-3171-0836)
- Jing Hu (ORCID: https://orcid.org/0000-0002-4119-4564)
- Ou Wang (ORCID: https://orcid.org/0000-0002-0395-8789)
- Bingna Zhou
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Fujian Provincial Hospital (CN)
Publication Details
- Journal
- Age and Ageing
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1093/ageing/afaf299
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00