Relationship Between Group 3 Innate Lymphoid Cells and Th17 in Human Nasopharynx-Associated Lymphoid Tissue and the Association With Pneumococcal Carriage
The abundance of NCR+ILC3 in the nasopharynx of children is positively associated with Sp carriage. The positive relationship between ILC3 and Sp may suggest an important role of ILC3 in the nasopharyngeal carriage of Sp, and further investigation is warranted. Understanding local interactions between ILC3 and ILC3-promoting Sp or ILC3-repressing S aureus may lead to novel therapeutics against nasopharyngeal carriage and disease.
Authors
- Isobel Marks (ORCID: https://orcid.org/0000-0002-3544-4512)
- Samuel Leong
- Madhan Krishnan (ORCID: https://orcid.org/0000-0003-3464-9329)
- Qibo Zhang (ORCID: https://orcid.org/0000-0003-0489-5086)
- Fábio Bagnoli (ORCID: https://orcid.org/0000-0002-6894-3780)
- Rong Xu (ORCID: https://orcid.org/0000-0002-9087-2982)
- Neil French (ORCID: https://orcid.org/0000-0003-4814-8293)
- Lualuaa Zaki
- Stephen Derbyshire
- Paul McNamara (ORCID: https://orcid.org/0000-0002-7055-6034)
- Ravi Sharma (ORCID: https://orcid.org/0000-0002-9047-3279)
Institutions
- University of Siena (IT)
- University of Liverpool (GB)
- Royal Surrey County Hospital (GB)
- University of Surrey (GB)
- Aintree University Hospital (GB)
- GlaxoSmithKline (India) (IN)
- Biology of Infection (FR)
- Alder Hey Children's Hospital (GB)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1093/infdis/jiaf488
- Primary Topic
- IL-33, ST2, and ILC Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00