Multi-omics profiling reveals downregulated tumor lysine metabolism reshaping the immune microenvironment and therapeutic responses in hepatocellular carcinoma
This study provides comprehensive evidence that lysine metabolism plays a critical role in shaping the immunosuppressive TIME in HCC and is associated with clinical outcomes and resistance to immunotherapy, offering new insights into clinical molecular subtyping and potential therapeutic strategies.
Authors
- Xinlan Lu (ORCID: https://orcid.org/0000-0002-8087-7800)
- Yungang Xu (ORCID: https://orcid.org/0000-0002-9834-3006)
- Kangsheng Tu (ORCID: https://orcid.org/0000-0002-0032-1459)
- Yufei Yao
- Changcheng Wang
- Rufeng Li
- Jiayi Wang
- Kang Li (ORCID: https://orcid.org/0000-0002-2960-3169)
- Yule Chen (ORCID: https://orcid.org/0000-0003-3515-4475)
- Chen Guo
- Min Qiang
Institutions
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1186/s12967-025-07056-3
- Citations
- 1
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- National Natural Science Foundation of China