Integrated Microbiome and metabolome analysis reveals Microbial-Metabolic interactions in psoriasis pathogenesis
This study highlights significant alterations in both the skin microbiome and metabolome in patients with psoriasis, revealing complex microbe-metabolite interaction networks. The findings suggest that microbial dysbiosis, particularly the decreased abundance of Cutibacterium and the increased abundance of Staphylococcus/Corynebacterium, may contribute to psoriasis pathogenesis by modulating lipid metabolism, inflammatory pathways, and oxidative stress responses.
Authors
- Guanzhi Chen
- Lei Zhang (ORCID: https://orcid.org/0000-0003-4284-2604)
- Fan Wu (ORCID: https://orcid.org/0000-0002-6671-5282)
- Xin Jiang (ORCID: https://orcid.org/0009-0004-1070-9141)
Institutions
- Qingdao University (CN)
- Shandong University (CN)
- Shandong Provincial Hospital (CN)
- Affiliated Hospital of Qingdao University (CN)
- Shandong First Medical University (CN)
- State Key Laboratory of Microbial Technology
Publication Details
- Journal
- BMC Microbiology
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1186/s12866-025-04395-5
- Citations
- 2
- Primary Topic
- Psoriasis: Treatment and Pathogenesis
- Type
- article
- Field-Weighted Citation Impact
- 1.59
Funders
- Shandong University
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province