Chelerythrine inhibits esophageal squamous cell carcinoma progression via PINK1-Parkin-mediated mitophagy
CHE activates PINK1-Parkin-mediated mitophagy and disrupts mitochondrial homeostasis, and it also affects the tumor environment and cell metabolism, ultimately leading to cell death, supporting the potential of CHE for ESCC therapy.
Authors
- Kuancan Liu (ORCID: https://orcid.org/0000-0002-2470-7479)
- Songlin Shi (ORCID: https://orcid.org/0000-0003-1213-0550)
- Yongpan Liu (ORCID: https://orcid.org/0000-0002-4892-2309)
- Yijian Zhou
- Zhuo Wang (ORCID: https://orcid.org/0000-0001-7258-8374)
- Yong Lin (ORCID: https://orcid.org/0000-0001-9171-0195)
- Hongzhou Zhao
- Jialing Xie (ORCID: https://orcid.org/0009-0008-2233-0824)
- Bo Zhang (ORCID: https://orcid.org/0000-0003-1288-1549)
- Kun Zhang (ORCID: https://orcid.org/0000-0002-1572-5878)
- Xinxin Li (ORCID: https://orcid.org/0000-0001-6760-0957)
- Lijia Zhang (ORCID: https://orcid.org/0000-0002-5728-6586)
- Xiaolu An
- Jiaying Zhang (ORCID: https://orcid.org/0009-0008-8122-2604)
Institutions
- Fujian Medical University (CN)
- Xiamen University (CN)
- First Affiliated Hospital of Xiamen University (CN)
- Fujian Business University (CN)
- Education Department of Fujian Province (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
- Xiamen University of Technology (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1186/s12967-025-07025-w
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Fujian Province
- Science Fund for Distinguished Young Scholars of Fujian Province