Identification and validation of SQLE in steroid-induced osteonecrosis of the femoral head: a bioinformatics and experimental study
This study reveals the role of SQLE in ONFH. Targeting SQLE, either through genetic silencing or pharmacological inhibition, alleviates osteoblast dysfunction and bone loss, providing a potential therapeutic strategy for ONFH.
Authors
- Weiguang Qiao (ORCID: https://orcid.org/0000-0001-8423-0724)
- Xuewen Shi (ORCID: https://orcid.org/0000-0002-3632-2859)
- Kui Zhang (ORCID: https://orcid.org/0000-0001-9618-610X)
- Wenji Wang (ORCID: https://orcid.org/0000-0003-1662-2130)
- Yanfei He (ORCID: https://orcid.org/0000-0002-0965-1200)
Institutions
- First Hospital of Lanzhou University (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1186/s13018-025-06305-x
- Citations
- 1
- Primary Topic
- Bone and Joint Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.72