Recurrent Asystole Without Generalized Dysautonomia in Anti‐ <scp>NMDA</scp> Receptor Encephalitis: A Case Report

ABSTRACT Background Life‐threatening arrhythmias in anti‐N‐methyl‐D‐aspartate receptor (NMDAR) encephalitis are typically regarded as part of a generalized autonomic storm. However, severe bradyarrhythmia occurring as the primary life‐threatening feature in the absence of a generalized autonomic storm is rare. Case Presentation A 27‐year‐old woman presented with a 2‐week history of neuropsychiatric symptoms. She was diagnosed with anti‐N‐methyl‐D‐aspartate receptor (NMDAR) encephalitis, supported by a positive cerebrospinal fluid (CSF) antibody test and an ovarian teratoma. Her hospital course was complicated by recurrent asystolic cardiac arrests, which occurred as the most critical feature of her autonomic instability and required temporary pacing. The patient recovered fully after immunotherapy and tumor resection. Conclusions This report identifies a critical diagnostic pitfall and highlights the necessity of continuous cardiac monitoring during the acute phase, even in patients who appear autonomically stable.

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Journal
Clinical and Experimental Neuroimmunology
Published
2025-10-17
DOI
https://doi.org/10.1111/cen3.70033
Primary Topic
Autoimmune Neurological Disorders and Treatments
Type
article
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article

Recurrent Asystole Without Generalized Dysautonomia in Anti‐ NMDA Receptor Encephalitis: A Case Report

Hirotaka Nakanishi, Tetsuya Oyama
Clinical and Experimental Neuroimmunology
Autoimmune Neurological Disorders and Treatments
article

Recurrent Asystole Without Generalized Dysautonomia in Anti‐ NMDA Receptor Encephalitis: A Case Report

Hirotaka Nakanishi, Tetsuya Oyama
article en

Abstract

ABSTRACT Background Life‐threatening arrhythmias in anti‐N‐methyl‐D‐aspartate receptor (NMDAR) encephalitis are typically regarded as part of a generalized autonomic storm. However, severe bradyarrhythmia occurring as the primary life‐threatening feature in the absence of a generalized autonomic storm is rare. Case Presentation A 27‐year‐old woman presented with a 2‐week history of neuropsychiatric symptoms. She was diagnosed with anti‐N‐methyl‐D‐aspartate receptor (NMDAR) encephalitis, supported by a positive cerebrospinal fluid (CSF) antibody test and an ovarian teratoma. Her hospital course was complicated by recurrent asystolic cardiac arrests, which occurred as the most critical feature of her autonomic instability and required temporary pacing. The patient recovered fully after immunotherapy and tumor resection. Conclusions This report identifies a critical diagnostic pitfall and highlights the necessity of continuous cardiac monitoring during the acute phase, even in patients who appear autonomically stable.

Clinical and Experimental NeuroimmunologyVol. 17(1)
Yokkaichi Municipal Hospital (JP)
Openalex Percentile: Top 58%
Autoimmune Neurological Disorders and Treatments
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Recurrent Asystole Without Generalized Dysautonomia in Anti‐ <scp>NMDA</scp> Receptor Encephalitis: A Case Report — Hirotaka Nakanishi, Tetsuya Oyama · Clinical and Experimental Neuroimmunology (2025) | TGRS Research Map | TGRS