Metabolomics of aortic valve stenosis: Are aortic valve stenosis and sclerosis different diseases?
Our study is the first to show that the levels of small HDL rather than plasma HDL concentration are significantly lower in AS patients. This suggests that small HDL may be one missing link in the pathophysiologic process between dyslipidemia and CAVD and generate innovative approaches for preventing CAVD. The results also prompt the question whether AS and ASc are distinct diseases.
Authors
- Juha E.K. Hartikainen (ORCID: https://orcid.org/0000-0003-0847-107X)
- Jaana Rysä (ORCID: https://orcid.org/0000-0003-2205-6323)
- Olli K. Kärkkäinen (ORCID: https://orcid.org/0000-0003-0825-4956)
- Retu Haikonen (ORCID: https://orcid.org/0000-0003-0830-3850)
- Elisa Koljonen (ORCID: https://orcid.org/0009-0003-2712-1320)
- Anu Turpeinen
Institutions
- University of Eastern Finland (FI)
- Kuopio University Hospital (FI)
Publication Details
- Journal
- Atherosclerosis
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1016/j.atherosclerosis.2025.120549
- Primary Topic
- Cardiac Valve Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00