Targeting Key Molecular Mechanisms in Triple-Negative Breast Cancer Therapies with Natural Compounds

Natural compounds are a promising supplementary method for TNBC therapy due to their ability to target unregulated pathways and overcome therapeutic resistance. Nevertheless, challenges such as pharmacokinetics, limited bioavailability, and a lack of clinical validation persist. Future research should focus on combinatorial regimens, nanocarrier-based delivery technologies, and biomarker-guided clinical trials to develop successful TNBC treatments.

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Publication Details

Journal
Current Pharmaceutical Design
Published
2025-10-14
DOI
https://doi.org/10.2174/0113816128411154250918060514
Citations
1
Primary Topic
Curcumin's Biomedical Applications
Type
article
Field-Weighted Citation Impact
0.59
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Targeting Key Molecular Mechanisms in Triple-Negative Breast Cancer Therapies with Natural Compounds

Nihar Ranjan Kar, Santosh Kumar Dash, Nezar Cherrada, Uttam Prasad Panigrahy et al.
1 citations
Current Pharmaceutical Design
Curcumin's Biomedical Applications
0.59
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Targeting Key Molecular Mechanisms in Triple-Negative Breast Cancer Therapies with Natural Compounds

Nihar Ranjan Kar, Santosh Kumar Dash, Nezar Cherrada, Uttam Prasad Panigrahy, Md. Fahim Faysal, Mehrukh Zehravi, A Padhan, Asim Khan, Talha Bin Emran, Sherouk Hussein Sweilam, Md. Zia Uddin, Md Al Amin, Safia Obaidur Rab
article en
1 citations

Abstract

Natural compounds are a promising supplementary method for TNBC therapy due to their ability to target unregulated pathways and overcome therapeutic resistance. Nevertheless, challenges such as pharmacokinetics, limited bioavailability, and a lack of clinical validation persist. Future research should focus on combinatorial regimens, nanocarrier-based delivery technologies, and biomarker-guided clinical trials to develop successful TNBC treatments.

Current Pharmaceutical DesignVol. 32
Prince Sattam Bin Abdulaziz University (SA), Daffodil International University (BD), Buraydah Colleges (SA), Hindu College of Pharmacy (IN), Centre Hospitalo-Universitaire Bab El Oued (DZ), University of Eloued (DZ), Centurion University of Technology and Management (IN), Assam Down Town University (IN), Life University (US), Egyptian Russian University (EG), King Khalid University (SA), University of Science and Technology Chittagong (BD)
Openalex Percentile: Top 29%
Curcumin's Biomedical Applications
0.59
DOISourceOpenAlex
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