Elucidating the role of APOE ε4 gene variants in the clinical manifestation of Parkinson's disease
The APOE ε4 allele is common in this preliminary study of 3 PD subjects. Our meta-analysis revealed a significantly earlier age-of-onset among APOE ε4 carriers relative to non-carriers, but no difference in disease severity and MMSE scores.
Authors
- Norikazu Hara (ORCID: https://orcid.org/0000-0001-8525-3469)
- Yusran Ady Fitrah (ORCID: https://orcid.org/0009-0001-2284-199X)
- Gita Vita Soraya (ORCID: https://orcid.org/0000-0002-2656-4176)
- Muhammad Nasrum Massi (ORCID: https://orcid.org/0000-0002-3347-6529)
- Takeshi Ikeuchi (ORCID: https://orcid.org/0000-0001-8828-8085)
- Zulvikar Syambani Ulhaq (ORCID: https://orcid.org/0000-0002-2659-1940)
- Andi Kurnia Bintang (ORCID: https://orcid.org/0000-0001-7010-4065)
- Akinori Miyashita (ORCID: https://orcid.org/0000-0003-2508-9649)
- Cahyono Kaelan
- Muhammad Akbar (ORCID: https://orcid.org/0000-0003-1159-2593)
- Jumraini Tammasse (ORCID: https://orcid.org/0009-0003-2785-8779)
- Ai Obinata
- Alfi Raudatil Jannah
Institutions
- National Emergency Management Agency (KR)
- Universitas Islam Makassar (ID)
- Niigata University (JP)
- Hasanuddin University (ID)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2025-10-17
- DOI
- https://doi.org/10.3389/fnagi.2025.1632480
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Agency for Medical Research and Development
- Universitas Hasanuddin
- Lembaga Pengelola Dana Pendidikan
- Israeli Centers for Research Excellence