An Exploration of Outlier Patients in Systemic Biomarkers of Chondral Metabolism After Anterior Cruciate Ligament Reconstruction
Outlier patients were observed when measuring all 3 systemic biomarkers of chondral metabolism after ACL reconstruction. For s-PIIANP and sMMP-3, outlier status was poorly explained by patient or surgical factors, but for u-CTX-II, outlier status could, in part, be explained by patient and surgical factors. These results support longitudinal biomarker analyses, given that outlier status can change over time, and this may not be identified in cross-sectional study designs.
Authors
- Andrew F. Hill (ORCID: https://orcid.org/0000-0001-5581-2354)
- Natasha Vassileff (ORCID: https://orcid.org/0000-0001-6554-4496)
- Haydn J. Klemm (ORCID: https://orcid.org/0009-0001-9074-3136)
- Lachlan M. Batty (ORCID: https://orcid.org/0000-0002-3914-1666)
- Brian M. Devitt (ORCID: https://orcid.org/0000-0003-2947-6996)
- Jereme G. Spiers (ORCID: https://orcid.org/0000-0001-5872-8983)
- Minh Huynh (ORCID: https://orcid.org/0000-0001-7349-7482)
- Julian A. Feller (ORCID: https://orcid.org/0000-0002-5737-4519)
- Kate E. Webster
- Timothy S. Whitehead
Institutions
- Australian National University (AU)
- La Trobe University (AU)
- Epworth Hospital (AU)
- St Vincent's Hospital Melbourne (AU)
- Footscray Hospital (AU)
- Western Health (AU)
- Sports Surgery Clinic (IE)
- Monash University (AU)
- Victoria University (AU)
Publication Details
- Journal
- The American Journal of Sports Medicine
- Published
- 2025-10-16
- DOI
- https://doi.org/10.1177/03635465251383532
- Citations
- 1
- Primary Topic
- Knee injuries and reconstruction techniques
- Type
- article
- Field-Weighted Citation Impact
- 2.01