Intranuclear paraspeckle‐circular RNA TACC3 assembly forms RNA‐DNA hybrids to facilitate MASH‐related hepatocellular carcinoma growth in an m <sup>6</sup> A‐dependent manner
The m<sup>6</sup>A modification-dependent circTACC3-paraspeckle assembly results in the formation of R loops at DSB foci, leading to chromatin remodeling and the activation of genes involved in MASH-related HCC malignant progression. This process identifies potential therapeutic targets.
Authors
- Man Zhang (ORCID: https://orcid.org/0000-0002-1346-706X)
- Yun Yang (ORCID: https://orcid.org/0000-0002-6314-0516)
- Haihua Qian (ORCID: https://orcid.org/0000-0001-5347-4830)
- Hao Song (ORCID: https://orcid.org/0000-0002-2811-0370)
- Jingbo Fu
- Miao Yu (ORCID: https://orcid.org/0000-0002-8547-6432)
- Tao Ouyang (ORCID: https://orcid.org/0000-0003-1836-338X)
- Zenglin Liu
- Yunfei Huo
- Kui Wang (ORCID: https://orcid.org/0000-0002-4756-9267)
- Shuo Xu (ORCID: https://orcid.org/0000-0003-0950-3846)
- Shuzhen Chen
- Hongyang Wang (ORCID: https://orcid.org/0000-0002-4709-3334)
- Xue Jiang
- Liang Li (ORCID: https://orcid.org/0000-0002-3079-1443)
- Yanping Wei (ORCID: https://orcid.org/0000-0002-7325-3557)
- Jing Fu (ORCID: https://orcid.org/0000-0001-7887-0266)
- Ru Zhao (ORCID: https://orcid.org/0000-0002-7576-2021)
- Yu Su (ORCID: https://orcid.org/0000-0003-4828-2433)
- Pinhua Yang
- Zhao Yang
- Xinwei Yang
- Xianming Wang
Institutions
- Second Military Medical University (CN)
- Shanghai Jiao Tong University (CN)
- Ministry of Education (SA)
- Shanghai Cancer Institute (CN)
- Eastern Hepatobiliary Surgery Hospital (CN)
- State Key Laboratory of Oncogene and Related Genes (CN)
- Shandong Provincial QianFoShan Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Cancer Communications
- Published
- 2025-10-16
- DOI
- https://doi.org/10.1002/cac2.70061
- Citations
- 1
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Natural Science Foundation of Shanghai