Targeting ER stress-mediated apoptosis by MSC-derived exosomes: A novel therapeutic strategy against pulmonary fibrosis
In conclusion, ER stress induced apoptosis in BLM-treated A549 cells, and MSC-Ex treatment mitigated apoptosis via inhibiting ER stress. This study provides a novel mechanism for MSC-Ex-mediated protection on apoptosis in an IPF model and suggests that MSC-Ex could be a promising therapeutic strategy for IPF.
Authors
- Ruixi Luo (ORCID: https://orcid.org/0000-0001-9052-1376)
- Didong Lou (ORCID: https://orcid.org/0000-0003-0059-1587)
- Weiyi Tian (ORCID: https://orcid.org/0000-0003-4074-2255)
- La Wang
- Peng Chen (ORCID: https://orcid.org/0000-0002-8210-8562)
- Yaqiong Wei
Institutions
- Guiyang College of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Regenerative Therapy
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1016/j.reth.2025.10.004
- Citations
- 1
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.81