Influence of age and antiepileptic comedication on lacosamide concentrations in children with epilepsy: A retrospective cohort study
Age and concomitant non-hepatic enzyme-inducing AEDs therapies significantly influence lacosamide exposure, underscoring the necessity for age-based dynamic dose optimization and rigorous evaluation of polypharmacy regimens to achieve precision therapeutics.
Authors
- Gang Nie (ORCID: https://orcid.org/0000-0002-5454-3786)
- Hui Peng (ORCID: https://orcid.org/0000-0002-4835-3409)
- Zhaosong Du
- Maochang Liu (ORCID: https://orcid.org/0000-0002-2371-4060)
- Jun Wang (ORCID: https://orcid.org/0000-0001-6796-5542)
- Ying Li (ORCID: https://orcid.org/0000-0002-1110-5524)
Institutions
- Wuhan Union Hospital (CN)
- Wuhan Children's Hospital (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-10-16
- DOI
- https://doi.org/10.1371/journal.pone.0333030
- Primary Topic
- Pharmacological Effects and Toxicity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00