Comparison the impact of IFN-β alone or in combination with vitamin D on critical pathways involved in AML progression

Our findings suggest that IFN-β effectively inhibits U937 cell proliferation and modulates key inflammatory and immune-related molecules involved in AML pathogenesis. These results highlight IFN-β as a promising agent for targeting critical pathways in AML and suggest a modulatory, but less potent role for Vit D.

Authors

Nafiseh Behranvand
Reza Falak (ORCID: https://orcid.org/0000-0002-1842-2952)
Farzad Nasri
Khodayar Ghorban (ORCID: https://orcid.org/0000-0003-3526-5597)
Maryam Dadmanesh (ORCID: https://orcid.org/0000-0002-0913-377X)
Hassan Jalaeikhoo
Negin Hosseini Rouzbahan
Yalda Babaei

Institutions

Iran University of Medical Sciences (IR)
Shahid Sadoughi University of Medical Sciences and Health Services (IR)
Aja University of Medical Sciences (IR)

Publication Details

Journal: PLoS ONE
Published: 2025-10-16
DOI: https://doi.org/10.1371/journal.pone.0330865
Primary Topic: Acute Myeloid Leukemia Research
Type: article
Field-Weighted Citation Impact: 0.00

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article

Comparison the impact of IFN-β alone or in combination with vitamin D on critical pathways involved in AML progression

Nafiseh Behranvand, Reza Falak, Farzad Nasri, Khodayar Ghorban et al.

Oct 16, 2025

PLoS ONE

Acute Myeloid Leukemia Research

article

Comparison the impact of IFN-β alone or in combination with vitamin D on critical pathways involved in AML progression

Nafiseh Behranvand, Reza Falak, Farzad Nasri, Khodayar Ghorban, Maryam Dadmanesh, Hassan Jalaeikhoo, Negin Hosseini Rouzbahan, Yalda Babaei

October 16, 2025article en

Abstract

Our findings suggest that IFN-β effectively inhibits U937 cell proliferation and modulates key inflammatory and immune-related molecules involved in AML pathogenesis. These results highlight IFN-β as a promising agent for targeting critical pathways in AML and suggest a modulatory, but less potent role for Vit D.

PLoS ONEVol. 20(10)

Iran University of Medical Sciences (IR), Shahid Sadoughi University of Medical Sciences and Health Services (IR), Aja University of Medical Sciences (IR)

Openalex Percentile: Top 63%

Acute Myeloid Leukemia Research

DOI Open Access PDF OpenAlex

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