<i>Lactobacillus rhamnosus</i> YQ001 binds with GII.4 human noroviruses and inhibits viral replication in zebrafish larvae
Human noroviruses (HuNoVs) are the leading cause of viral gastroenteritis globally, yet effective antiviral treatments remain limited. The current study demonstrated that <i>Lactobacillus rhamnosus</i> YQ001 could inhibit GII.4 HuNoV replication in zebrafish larvae. The cell-free supernatant and membrane proteins originated from <i>L. rhamnosus</i> YQ001 did work synergistically in GII.4 HuNoVs control. The membrane proteins could bind to the viral capsid. These findings offer a unique insight into the antiviral mechanisms of <i>L. rhamnosus</i> YQ001, laying the groundwork for developing probiotic-based foods to anti-HuNoVs.
Authors
- Yue Liu (ORCID: https://orcid.org/0000-0001-8518-5734)
- Yutong Yang
- Chenang Lyu (ORCID: https://orcid.org/0000-0001-5328-9993)
- Mengge Sun (ORCID: https://orcid.org/0000-0003-2777-608X)
- Dapeng Wang (ORCID: https://orcid.org/0000-0003-2015-0033)
- Ran An (ORCID: https://orcid.org/0000-0002-5475-3353)
- Qinghua Zhang (ORCID: https://orcid.org/0000-0002-6416-9134)
- Lin Yao
- Yaqi Yang (ORCID: https://orcid.org/0009-0005-4790-9582)
- Shang Chen (ORCID: https://orcid.org/0000-0001-9307-5666)
- Xiangjun Zhan
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai Ocean University (CN)
- Chinese Academy of Fishery Sciences (CN)
Publication Details
- Journal
- Applied and Environmental Microbiology
- Published
- 2025-10-16
- DOI
- https://doi.org/10.1128/aem.01046-25
- Primary Topic
- Viral gastroenteritis research and epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00