Cholesterol oxidase treatment impairs CXCR4-mediated T cell migration
This study identifies cholesterol as a crucial regulator of CXCR4 lateral mobility and spatial organization, enabling cells to effectively sense chemoattractant gradients.
Authors
- Blanca Soler Palacios (ORCID: https://orcid.org/0000-0001-6031-1896)
- Adriana Quijada‐Freire (ORCID: https://orcid.org/0000-0001-6709-5620)
- José Miguel Rodríguez‐Frade (ORCID: https://orcid.org/0000-0002-7753-1462)
- Mario Mellado (ORCID: https://orcid.org/0000-0001-6325-1630)
- Sofía R. Gardeta (ORCID: https://orcid.org/0000-0003-1166-4809)
- Rosa Ayala-Bueno (ORCID: https://orcid.org/0000-0002-7902-2784)
- Eva M. García‐Cuesta (ORCID: https://orcid.org/0000-0003-2311-4353)
- Noelia Santander Acerete
Institutions
- Centro Nacional de Biotecnología (ES)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1186/s12964-025-02392-9
- Citations
- 1
- Primary Topic
- Receptor Mechanisms and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Ministerio de Ciencia, Innovación y Universidades
- Universidad Autónoma de Madrid
- Ministerio de Ciencia e Innovación
- European Regional Development Fund
- Agencia Estatal de Investigación