Longitudinal characterization of inflammatory plasma protein signatures in ECT response
Symptom improvement during ECT is associated with reductions in specific inflammatory and neuroimmune markers, suggesting a potential link to the therapeutic mechanisms. These findings provide preliminary indications of immune involvement in ECT and emphasize the need for larger cohorts to validate results and further investigate immunomodulatory targets in psychiatric treatment.
Authors
- Bruno Pedraz‐Petrozzi
- Klaus Peter Lieb (ORCID: https://orcid.org/0000-0002-9609-4261)
- Eric Zillich (ORCID: https://orcid.org/0000-0003-3704-7243)
- Josef Frank (ORCID: https://orcid.org/0000-0003-4867-9465)
- Hanna Belschner
- Antonia Franziska Eckert (ORCID: https://orcid.org/0000-0002-9521-4321)
- Lea Sirignano (ORCID: https://orcid.org/0000-0002-7989-5833)
- K Kachel
- Else Schneider (ORCID: https://orcid.org/0000-0001-7550-9272)
- Stephanie H. Witt (ORCID: https://orcid.org/0000-0002-1571-1468)
- Annette Beatrix Brühl (ORCID: https://orcid.org/0000-0003-4704-4986)
- Alexander Sartorius (ORCID: https://orcid.org/0000-0002-1243-3693)
- Sabrina Karl (ORCID: https://orcid.org/0000-0002-7619-728X)
- Helene Dukal (ORCID: https://orcid.org/0000-0002-6188-807X)
- Lea Zillich (ORCID: https://orcid.org/0000-0001-7457-374X)
- Jan Engelmann (ORCID: https://orcid.org/0000-0001-8818-0138)
- Nicole Ziegler (ORCID: https://orcid.org/0009-0002-4626-8793)
Institutions
- University of Basel (CH)
- Johannes Gutenberg University Mainz (DE)
- Heidelberg University (DE)
- University Medical Center Freiburg (DE)
- University Hospital Heidelberg (DE)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- Central Institute of Mental Health (DE)
- Fraunhofer Institute for Translational Medicine and Pharmacology (DE)
- Universitäre Psychiatrische Kliniken Basel (CH)
Publication Details
- Journal
- Journal of Affective Disorders
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1016/j.jad.2025.120494
- Primary Topic
- Electroconvulsive Therapy Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00