A comprehensive compilation of data on the association between XRCC3 polymorphisms and thyroid cancer susceptibility

XRCC3 rs1799794 polymorphism is associated with increased thyroid cancer risk, particularly under recessive genetic models. The rs1799796 variant may confer a protective effect in Asian populations, whereas rs861539 shows no significant association. These results highlight population-specific genetic effects and underscore the importance of considering ethnicity in genetic association studies. Further large, well-designed investigations are warranted to confirm these findings and to explore potential gene-environment interactions.

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Publication Details

Journal
BMC Endocrine Disorders
Published
2025-10-16
DOI
https://doi.org/10.1186/s12902-025-02044-6
Primary Topic
DNA Repair Mechanisms
Type
article
Field-Weighted Citation Impact
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article

A comprehensive compilation of data on the association between XRCC3 polymorphisms and thyroid cancer susceptibility

Seyed Masoud HaghighiKian, Bahareh Mehdikhani, Hossein Neámatzadeh, Alireza Nezameslami et al.
BMC Endocrine Disorders
DNA Repair Mechanisms
article

A comprehensive compilation of data on the association between XRCC3 polymorphisms and thyroid cancer susceptibility

Seyed Masoud HaghighiKian, Bahareh Mehdikhani, Hossein Neámatzadeh, Alireza Nezameslami, Amirhossein Rahmani, Alireza Negahi, Amirmasoud Shiri, Mohammad Vakili-Ojarood, Abbas Shahbazi, Amirhosein Naseri, Rezvan Nezameslami, Mahdi Khosravi-Mashzi
article en

Abstract

XRCC3 rs1799794 polymorphism is associated with increased thyroid cancer risk, particularly under recessive genetic models. The rs1799796 variant may confer a protective effect in Asian populations, whereas rs861539 shows no significant association. These results highlight population-specific genetic effects and underscore the importance of considering ethnicity in genetic association studies. Further large, well-designed investigations are warranted to confirm these findings and to explore potential gene-environment interactions.

BMC Endocrine DisordersVol. 25(1)
Iran University of Medical Sciences (IR), Shiraz University of Medical Sciences (IR), Shahid Sadoughi University of Medical Sciences and Health Services (IR), Medical University of Ilam (IR), Ardabil University of Medical Sciences (IR), Iranshahr University (IR), Farabi Hospital (IR), Ilam University (IR), Imam Reza Hospital (IR), Imam Hossein Hospital (IR), Shahid Beheshti University of Medical Sciences (IR), Tehran University of Medical Sciences (IR)
Openalex Percentile: Top 74%
DNA Repair Mechanisms
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A comprehensive compilation of data on the association between XRCC3 polymorphisms and thyroid cancer susceptibility — Seyed Masoud HaghighiKian, Bahareh Mehdikhani, et al. · BMC Endocrine Disorders (2025) | TGRS Research Map | TGRS