Multimodal microscope for optical coherence microscopy, tomography, vibrometry, and two-photon microscopy in the living mouse cochlea
Automation and optimization of the optical system enabled seamless multiscale imaging of the murine cochlea, providing high-quality morphological, functional, and two-photon fluorescence images. The dynamic adjustment of the beam diameter within the microscope was essential for maintaining high SNR across a wide range of numerical apertures.
Authors
- John S. Oghalai (ORCID: https://orcid.org/0000-0003-4241-6189)
- Patricia M. Quiñones
- Michael J. Serafino
- Brian E. Applegate (ORCID: https://orcid.org/0000-0003-2795-5678)
- Clayton B. Walker (ORCID: https://orcid.org/0000-0003-1137-9071)
- James B. Dewey (ORCID: https://orcid.org/0000-0001-5715-9125)
Institutions
- University of Southern California (US)
- Texas A&M University (US)
Publication Details
- Journal
- Journal of Biomedical Optics
- Published
- 2025-10-16
- DOI
- https://doi.org/10.1117/1.jbo.30.10.106005
- Primary Topic
- Optical Coherence Tomography Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute on Deafness and Other Communication Disorders