Artificial Intelligence-Based Echocardiographic Assessment for Monitoring Disease Progression in Transthyretin Cardiac Amyloidosis
A ≥5% decrease of AI-derived LVOT-VTI over 12 months, a simple indicator of SV loss, is independently associated with worse outcome in ATTR-CM. Routine monitoring of this automated AI metric may guide earlier therapeutic escalation and is a possible endpoint for future trials.
Authors
- Adam Ioannou (ORCID: https://orcid.org/0000-0001-5017-8657)
- Josephine Mansell (ORCID: https://orcid.org/0000-0002-1778-3713)
- Justin Adrian Ezekowitz (ORCID: https://orcid.org/0000-0002-2724-4086)
- Helen Jane Lachmann (ORCID: https://orcid.org/0000-0001-8378-2498)
- Ashutosh Wechelakar
- Francesco Bandera (ORCID: https://orcid.org/0000-0002-5821-7371)
- Lucia Venneri (ORCID: https://orcid.org/0009-0006-2551-7403)
- İrem Okçular Sezer (ORCID: https://orcid.org/0000-0002-3116-8135)
- Awais Sheikh (ORCID: https://orcid.org/0000-0002-7707-226X)
- Philip N. Hawkins (ORCID: https://orcid.org/0000-0002-6983-9598)
- Michele Emdin
- Scott David Solomon (ORCID: https://orcid.org/0000-0003-3698-9597)
- Julian D. Gillmore (ORCID: https://orcid.org/0000-0001-6174-9232)
- Carol Jane Whelan (ORCID: https://orcid.org/0000-0002-9743-9567)
- Seethalakshmi Iyer
- Carolyn S.P. Lam (ORCID: https://orcid.org/0000-0003-1903-0018)
- Yousuf Razvi (ORCID: https://orcid.org/0000-0003-4766-3293)
- Aldostefano Porcari (ORCID: https://orcid.org/0000-0003-3307-0825)
- Matthew Frost (ORCID: https://orcid.org/0000-0003-0382-6329)
- William E. Moody (ORCID: https://orcid.org/0000-0002-2592-618X)
- Alberto Aimo (ORCID: https://orcid.org/0000-0001-9129-9519)
- Ana Martinez–Naharro (ORCID: https://orcid.org/0000-0003-3595-6988)
- See Lim
- Marianna Fontana
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- University of Alberta (CA)
- Scuola Superiore Sant'Anna (IT)
- University of Milan (IT)
- Queen Elizabeth Hospital Birmingham (GB)
- The Royal Free Hospital (GB)
- MultiMedica (IT)
- Equilibrium Research (GB)
- National Heart Centre Singapore (SG)
- Fondazione Toscana Gabriele Monasterio (IT)
- University College London (GB)
- University of Birmingham (GB)
Publication Details
- Journal
- European Journal of Heart Failure
- Published
- 2025-10-16
- DOI
- https://doi.org/10.1002/ejhf.70073
- Citations
- 3
- Primary Topic
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- AstraZeneca