The Role of Incidental Magnetization Transfer in Divided Subtracted Inversion Recovery

Divided subtracted inversion recovery (dSIR) images show abnormal changes in the white matter of the brain in patients with mild traumatic brain injury (mTBI) due to an increase in the apparent T<sub>1</sub> compared to normal controls. The present study aims to understand the origin of the T<sub>1</sub> difference in terms of incidental magnetization transfer (MT). Results show that white matter in normal controls has dSIR signal (T<sub>1</sub>), attributable to MT, while patients with mTBI exhibit little or no reduction. The study identifies a plausible mechanism for the dSIR signal differences. This may lead to more effective magnetic resonance imaging (MRI) methods for detecting mTBI and other conditions affecting the brain.

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Publication Details

Journal
NMR in Biomedicine
Published
2025-10-16
DOI
https://doi.org/10.1002/nbm.70165
Primary Topic
Advanced MRI Techniques and Applications
Type
article
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article

The Role of Incidental Magnetization Transfer in Divided Subtracted Inversion Recovery

Gil Newburn, Tracy R. Melzer, Samantha J. Holdsworth, Olivier M. Girard et al.
NMR in Biomedicine
Advanced MRI Techniques and Applications
article

The Role of Incidental Magnetization Transfer in Divided Subtracted Inversion Recovery

Gil Newburn, Tracy R. Melzer, Samantha J. Holdsworth, Olivier M. Girard, Daniel Cornfeld, Maryam Tayebi, Graeme M. Bydder, Paul Condron, Mark Bydder, Nickolas J. Palmer, Eryn Kwon, Taylor Emsden
article en

Abstract

Divided subtracted inversion recovery (dSIR) images show abnormal changes in the white matter of the brain in patients with mild traumatic brain injury (mTBI) due to an increase in the apparent T<sub>1</sub> compared to normal controls. The present study aims to understand the origin of the T<sub>1</sub> difference in terms of incidental magnetization transfer (MT). Results show that white matter in normal controls has dSIR signal (T<sub>1</sub>), attributable to MT, while patients with mTBI exhibit little or no reduction. The study identifies a plausible mechanism for the dSIR signal differences. This may lead to more effective magnetic resonance imaging (MRI) methods for detecting mTBI and other conditions affecting the brain.

NMR in BiomedicineVol. 38(12)
Centre National de la Recherche Scientifique (FR), University of Auckland (NZ), University of Canterbury (NZ), Aix-Marseille Université (FR), University of California San Diego (US), Pacific Radiology (New Zealand) (NZ), New Zealand Brain Research Institute (NZ), Medical Research Institute of New Zealand (NZ), Mātai Medical Research Institute, University of Otago (NZ)
Openalex Percentile: Top 57%
Advanced MRI Techniques and Applications
DOIOpen Access PDFOpenAlex
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The Role of Incidental Magnetization Transfer in Divided Subtracted Inversion Recovery — Gil Newburn, Tracy R. Melzer, et al. · NMR in Biomedicine (2025) | TGRS Research Map | TGRS