Time-of-day and age-related patterns in cerebrospinal fluid glucose and protein
Higher CSF glucose from 00:00-08:00 and 16:00-00:00 compared to 08:00-16:00 suggests diurnal fluctuations which may be driven by a circadian rhythm. A higher CSF protein concentration was strongly associated with increasing age, without clear time-of-day variations. These results have implications for clinical interpretation and future research of the role of CSF in health and disease.
Authors
- Thanda Meehan
- Maren E. Loe (ORCID: https://orcid.org/0000-0002-1550-8646)
- Erik S. Musiek (ORCID: https://orcid.org/0000-0002-8873-0360)
- Shelei Pan (ORCID: https://orcid.org/0000-0002-7318-1944)
- Joshua P. Koleske (ORCID: https://orcid.org/0009-0004-8133-1801)
- Brendan P. Lucey (ORCID: https://orcid.org/0000-0001-5400-825X)
- Jennifer M. Strahle (ORCID: https://orcid.org/0000-0002-0527-7936)
- Diego M. Morales (ORCID: https://orcid.org/0000-0001-6672-9046)
Institutions
- Washington University in St. Louis (US)
Publication Details
- Journal
- Fluids and Barriers of the CNS
- Published
- 2025-10-16
- DOI
- https://doi.org/10.1186/s12987-025-00686-1
- Primary Topic
- Neurological and metabolic disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Washington University in St. Louis