Androgen receptors protect against thoracic aortic dissection via inhibiting ferroptosis of vascular smooth muscle cells in male patients
Our results reveal a previously unrecognized role of AR in TAD pathogenesis and uncover the opposite yet complementary regulation of ACSL3/ACSL4 levels involved in lipid peroxidation-driven ferroptosis in VSMCs.
Authors
- Wai Ho Tang (ORCID: https://orcid.org/0000-0002-2168-3491)
- Yiping Zhao (ORCID: https://orcid.org/0000-0003-3723-6415)
- Zhexin Lu (ORCID: https://orcid.org/0000-0002-0314-8129)
- Haozhe Qi
- Jiaquan Chen (ORCID: https://orcid.org/0000-0002-6151-4529)
- Lan Zhang (ORCID: https://orcid.org/0000-0002-5094-8524)
- Meng Ye (ORCID: https://orcid.org/0000-0002-8125-6854)
- Yinan Li (ORCID: https://orcid.org/0000-0002-3244-1228)
- Yuli Wang (ORCID: https://orcid.org/0000-0001-5307-1345)
- Weilun Wang (ORCID: https://orcid.org/0000-0002-8864-4374)
- Yizhou Ye (ORCID: https://orcid.org/0009-0008-6755-1604)
- Yongjie Yao (ORCID: https://orcid.org/0000-0002-6729-4467)
- Xiangjiang Guo
- Qihong Ni (ORCID: https://orcid.org/0000-0002-5420-0708)
- Shuofei Yang (ORCID: https://orcid.org/0000-0002-7897-3991)
- Guanhua Xue (ORCID: https://orcid.org/0000-0003-0272-3109)
- Lei Lyv
Institutions
- Renji Hospital (CN)
- Shanghai Chest Hospital (CN)
- Guangzhou Women and Children Medical Center (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Chinese Medical Journal
- Published
- 2025-10-16
- DOI
- https://doi.org/10.1097/cm9.0000000000003749
- Citations
- 1
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.94