Efficacy of <i>Serenoa repens</i> Extract Combined With Alfuzosin Versus Alfuzosin Alone in Men With Lower Urinary Tract Symptoms Due to Benign Prostatic Hyperplasia: A Multicenter Randomized Study
The combination of HESr and alfuzosin was significantly more effective than alfuzosin monotherapy in relieving LUTS, with greater benefits from Month 3 onward. Q<sub>max</sub> and nocturia also showed greater, although mild, improvements with combination therapy. Sexual function outcomes were comparable between groups. High adherence and real-world applicability support the clinical value of this combination in managing BPH-related LUTS.
Authors
- Ervin Shehu
- Stefano Signore (ORCID: https://orcid.org/0000-0002-0455-7258)
- Dalila Carino (ORCID: https://orcid.org/0009-0007-4043-6625)
- Alessandro Sciarra (ORCID: https://orcid.org/0000-0002-7899-8056)
- Flavio Forte
- Marco Frisenda (ORCID: https://orcid.org/0000-0002-8225-1174)
- Olivia Alessandra Voglino
- Antonio Luigi Pastore (ORCID: https://orcid.org/0000-0003-4293-9174)
- Massimiliano Di Marco
- Pietro Viscuso (ORCID: https://orcid.org/0000-0002-1252-1511)
- Fabio Maria Valenzi (ORCID: https://orcid.org/0009-0005-5830-0975)
- M. Martini (ORCID: https://orcid.org/0000-0001-9122-8163)
- Fabrizio Presicce (ORCID: https://orcid.org/0000-0002-5040-0956)
- Alessandro Calarco (ORCID: https://orcid.org/0000-0001-6893-2179)
- Giulio Bevilacqua
- Alessandro Gentilucci
- Martino Recchia
Institutions
- University of Milan (IT)
- Mario Negri Institute for Pharmacological Research (IT)
- Ospedale San Filippo Neri (IT)
- Ospedale San Carlo (IT)
- Ospedale Cristo Re (IT)
- IRCCS San Camillo Hospital (IT)
- Nini Hospital (LB)
- St. Eugenio Hospital (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- The Prostate
- Published
- 2025-10-16
- DOI
- https://doi.org/10.1002/pros.70071
- Citations
- 1
- Primary Topic
- Urinary Bladder and Prostate Research
- Type
- article
- Field-Weighted Citation Impact
- 1.84