Fusobacterium nucleatum enhances oxaliplatin resistance in colon cancer by increasing PVT1 expression
This study delineates a pathway where Fn infection promotes oxaliplatin resistancein colon cancer cells by upregulating PVT1 via the TLR4/NF-κB pathway. PVT1 subsequently stabilizes ATAD3A, suppressing cell death. PVT1 is a potential target to overcome the high abundance of Fusobacterium nucleatum leading to oxaliplatin resistance in colon cancer.
Authors
- Kewei Gao (ORCID: https://orcid.org/0000-0002-0606-2849)
- Chen Liu (ORCID: https://orcid.org/0000-0001-8131-6610)
- Jianfeng Zhang (ORCID: https://orcid.org/0000-0002-3270-0533)
- Yang Yang (ORCID: https://orcid.org/0000-0001-6417-3654)
- Feifei Wang (ORCID: https://orcid.org/0000-0002-2351-6873)
- Jianlong Wang (ORCID: https://orcid.org/0000-0003-3529-542X)
- Guiying Wang (ORCID: https://orcid.org/0000-0001-9601-8210)
- Lianmei Zhao (ORCID: https://orcid.org/0000-0002-9363-9588)
- Hongqing Ma
- Jianqing Zhang
Institutions
- Hebei Medical University (CN)
- Third Hospital of Hebei Medical University (CN)
- Second Hospital of Hebei Medical University (CN)
- Fourth Hospital of Hebei Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-10-16
- DOI
- https://doi.org/10.1186/s12967-025-07226-3
- Citations
- 1
- Primary Topic
- Gastric Cancer Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hebei Province
- Hebei Medical University