Comparative virulence study of locally circulating peste des petits ruminants virus (PPRV) strains in indigenous Ethiopian goats
This first comparative study of Ethiopian PPRV strains establishes similar virulence profiles across lineages in local goats, suggesting that lineage classification alone may not predict clinical outcomes-an important finding for regional disease control strategies. The reduced virulence in one strain suggests factors beyond genomic lineage may influence experimental outcomes, though additional work with standardized protocols is needed to confirm these findings.
Authors
- Demeke Sibhatu
- Abde Aliy Mohammed
- Dereje Shegu (ORCID: https://orcid.org/0000-0002-2907-6151)
- Tesfaye Rufael (ORCID: https://orcid.org/0000-0001-7865-4301)
- Menbere Kidane
- Redeat Belaineh
- Getnet Abie Mekonnen (ORCID: https://orcid.org/0000-0002-7605-5433)
- Hagos Asgedom
- Catherine M. Herzog (ORCID: https://orcid.org/0000-0003-3021-888X)
- Maurice Byukusenge (ORCID: https://orcid.org/0000-0002-2548-1299)
- Hassen Chaka
- Asegedech Sirak
- Hagos Ashenafi (ORCID: https://orcid.org/0000-0002-4377-5434)
- Tesfu Kassa (ORCID: https://orcid.org/0000-0001-7349-7706)
- Fasil Aklilu
- Solomon Gebredufe
Institutions
- Pennsylvania State University (US)
- Ethiopian Public Health Institute (ET)
- Animal Health Institute (US)
- Addis Ababa University (ET)
Publication Details
- Journal
- BMC Veterinary Research
- Published
- 2025-10-16
- DOI
- https://doi.org/10.1186/s12917-025-05073-4
- Primary Topic
- Virology and Viral Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00