The Effect of Prophylactic Use of NSAIDs on Acute Phase Reactions Induced by First-Time Zoledronic Acid Treatment for Osteoporosis

Prophylactic NSAIDs significantly reduce zoledronic acid-induced APRs, especially pain, but have no significant effect on preventing fever. The 3 NSAIDs also have comparable efficacy.

Authors

Weiyang Zhang (ORCID: https://orcid.org/0000-0001-8670-7055)
Wencan Lu (ORCID: https://orcid.org/0000-0001-8413-4177)
Qiuling Wang (ORCID: https://orcid.org/0000-0001-7696-8737)
Weipeng Ai

Institutions

Shenzhen University (CN)

Publication Details

Journal: Annals of Pharmacotherapy
Published: 2025-10-16
DOI: https://doi.org/10.1177/10600280251367582
Primary Topic: Bone health and treatments
Type: article
Field-Weighted Citation Impact: 0.00

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article

The Effect of Prophylactic Use of NSAIDs on Acute Phase Reactions Induced by First-Time Zoledronic Acid Treatment for Osteoporosis

Weiyang Zhang, Wencan Lu, Qiuling Wang, Weipeng Ai

Oct 16, 2025

Annals of Pharmacotherapy

Bone health and treatments

article

The Effect of Prophylactic Use of NSAIDs on Acute Phase Reactions Induced by First-Time Zoledronic Acid Treatment for Osteoporosis

Weiyang Zhang, Wencan Lu, Qiuling Wang, Weipeng Ai

October 16, 2025article en

Abstract

Prophylactic NSAIDs significantly reduce zoledronic acid-induced APRs, especially pain, but have no significant effect on preventing fever. The 3 NSAIDs also have comparable efficacy.

Annals of Pharmacotherapy

Shenzhen University (CN)

Openalex Percentile: Top 60%

Bone health and treatments

DOI Source OpenAlex

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The Effect of Prophylactic Use of NSAIDs on Acute Phase Reactions Induced by First-Time Zoledronic Acid Treatment for Osteoporosis — Weiyang Zhang, Wencan Lu, et al. · Annals of Pharmacotherapy (2025) | TGRS Research Map | TGRS