Chronic kidney disease is associated with increased risk of sudden cardiac death

Patients with chronic kidney disease (CKD) are recognized as a higher risk group for cardiovascular disease (CVD) due to various traditional risk factors, kidney-specific factors, and comorbidities, which have recently attracted significant attention. However, the long-term risk of acute CVD events such as sudden cardiac death (SCD) in CKD patients is unclear. Using the UK Biobank and Changsha cohorts, we find that CKD is associated with an increased risk of SCD. Patients with early-stage CKD, especially those with advanced CKD, faced an elevated risk of SCD. Furthermore, through proteomic analyses of the UK Biobank and Framingham Offspring Cohort, we identify five candidate proteins (NTproBNP, ANGPT2, FGF23, DTNB, and SEPTIN8) linked to SCD risk in CKD patients. Here, we show that patients with CKD have an increased risk of SCD in the long term, underscoring the imperative for strategies that address both cardiovascular risk and renal function in this population.

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Publication Details

Journal
Nature Communications
Published
2025-10-16
DOI
https://doi.org/10.1038/s41467-025-64254-9
Primary Topic
Chronic Kidney Disease and Diabetes
Type
article
Field-Weighted Citation Impact
0.00

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article

Chronic kidney disease is associated with increased risk of sudden cardiac death

Chenxi Ouyang, Ru‐Chao Jiang, Qingwei Yu, Jingjing Cai et al.
Nature Communications
Chronic Kidney Disease and Diabetes
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Chronic kidney disease is associated with increased risk of sudden cardiac death

Chenxi Ouyang, Ru‐Chao Jiang, Qingwei Yu, Jingjing Cai, Yao Lu, Li Zhang, Hong Yuan, Yan Chen, Jie Wang, Shiqi Liu, Yalan Li, Hong Wei, Jun Lü
article en

Abstract

Patients with chronic kidney disease (CKD) are recognized as a higher risk group for cardiovascular disease (CVD) due to various traditional risk factors, kidney-specific factors, and comorbidities, which have recently attracted significant attention. However, the long-term risk of acute CVD events such as sudden cardiac death (SCD) in CKD patients is unclear. Using the UK Biobank and Changsha cohorts, we find that CKD is associated with an increased risk of SCD. Patients with early-stage CKD, especially those with advanced CKD, faced an elevated risk of SCD. Furthermore, through proteomic analyses of the UK Biobank and Framingham Offspring Cohort, we identify five candidate proteins (NTproBNP, ANGPT2, FGF23, DTNB, and SEPTIN8) linked to SCD risk in CKD patients. Here, we show that patients with CKD have an increased risk of SCD in the long term, underscoring the imperative for strategies that address both cardiovascular risk and renal function in this population.

Nature CommunicationsVol. 16(1)
Central South University (CN), XinHua Hospital (CN), Suzhou Municipal Hospital (CN), Jiangsu Province Hospital (CN), Third Xiangya Hospital (CN), Nanjing Medical University (CN)
National Natural Science Foundation of China, Central South University, National Science and Technology Major Project
Openalex Percentile: Top 69%
Chronic Kidney Disease and Diabetes
DOIOpen Access PDFOpenAlex
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