Differential Outcomes of Beta-Blockers According to Heart Rate Following Myocardial Infarction with Reduced Left Ventricular Ejection Fraction
In patients with AMI-rEF, beta-blockers were not independently associated with significantly reduced all-cause death after adjustment, though a trend was observed. Notably, beta-blocker use increased the risk of nonfatal myocardial infarction, particularly at higher H-R. These findings suggest that the benefits of beta-blockers in this population may not be uniform and highlight the potential importance of H-R as a clinical marker to guide individualized beta-blocker use in the contemporary post-AMI setting.
Authors
- Seok Oh (ORCID: https://orcid.org/0000-0002-6193-2982)
- Doo Sun Sim (ORCID: https://orcid.org/0000-0003-4162-7902)
- Ju Han Kim (ORCID: https://orcid.org/0000-0002-3186-0770)
- Youngkeun Ahn (ORCID: https://orcid.org/0000-0003-2022-9366)
- Min Chul Kim (ORCID: https://orcid.org/0000-0001-6026-1702)
- Myung Ho Jeong (ORCID: https://orcid.org/0000-0003-2424-810X)
- Kyung Hoon Cho (ORCID: https://orcid.org/0000-0002-0377-6352)
- Young Joon Hong (ORCID: https://orcid.org/0000-0003-0192-8161)
Institutions
- Chonnam National University (KR)
- Chonnam National University Hospital (KR)
- Veterans Health Service Medical Center (KR)
- Monash University (AU)
Publication Details
- Journal
- Cardiovascular Drugs and Therapy
- Published
- 2025-10-16
- DOI
- https://doi.org/10.1007/s10557-025-07791-1
- Citations
- 1
- Primary Topic
- Heart rate and cardiovascular health
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Chonnam National University
- Iran Telecommunication Research Center
- Ministry of Science and ICT, South Korea
- National Institutes of Health
- Centers for Disease Control and Prevention
- Korea Centers for Disease Control and Prevention
- Institute for Information and Communications Technology Promotion