Aza-peptide aldehydes and ketones: synthesis and evaluation as human 20S proteasome inhibitors
Overall, aza-peptide aldehydes and ketones are a new class of selective human c20S proteasome inhibitors with the potential for further development as alternative therapeutics for multiple myeloma.
Authors
- Conor R. Caffrey (ORCID: https://orcid.org/0000-0003-3048-8572)
- Leilani Lotti Díaz (ORCID: https://orcid.org/0000-0001-5955-9595)
- Özlem Doǧan Ekici (ORCID: https://orcid.org/0000-0002-1237-1269)
- Kayla Q. Kasper
- Joseph Fernandez (ORCID: https://orcid.org/0000-0002-3744-3206)
- Anthony J. O’Donoghue (ORCID: https://orcid.org/0000-0001-5695-0409)
- Moyer S. Fleisher
- Christopher M. Hadad (ORCID: https://orcid.org/0000-0003-1211-4315)
- Thomas S. Corrigan (ORCID: https://orcid.org/0000-0001-5113-9406)
- Sarah E. Border (ORCID: https://orcid.org/0000-0001-5739-3093)
- Abigail R. Miller (ORCID: https://orcid.org/0009-0007-2302-635X)
- Kayla S. Kucway
- Alex R. Lovins (ORCID: https://orcid.org/0009-0002-5850-1708)
- RababM Amer
- Don M. Benson
- Ana K. Serrano
Institutions
- The Ohio State University Wexner Medical Center (US)
- University of California San Diego (US)
- The Ohio State University Newark (US)
- The Ohio State University (US)
- University of Montana (US)
Publication Details
- Journal
- Future Medicinal Chemistry
- Published
- 2025-10-16
- DOI
- https://doi.org/10.1080/17568919.2025.2561542
- Citations
- 1
- Primary Topic
- Ubiquitin and proteasome pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.81